Association between interleukin-10-3575T>A (rs1800890) polymorphism and cancer risk.

Abstract

BACKGROUND:

Previous studies investigated the associations of interleukin-10 (IL-10) polymorphisms with different types of cancer, indicating an influence on cancer risk. IL-10-3575T>A (rs1800890) has been studied concerning a potential implication in terms of some cancer site risks, but the results from single studies are contradictory.

METHODS:

Eligible articles were identified by a search of the PubMed, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) databases until November 30, 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the cancer risk by cancer sites, ethnicity, and other study features.

RESULTS:

We identified 15 published studies to research the link of the IL-10-3575T>A polymorphism with cancer risk. Our meta-analysis indicated that the IL-10-3575T>A polymorphism has a significant association with decreased melanoma risk in the heterozygote model (OR=0.67, 95% CI=0.49-0.92, p=0.02) and dominant model (OR=0.70, 95% CI=0.52-0.95, p=0.01), but increased diffuse large B-cell lymphoma (DLBCL) risk in all the different genetic models.

CONCLUSION:

Our analysis suggests that the IL-10-3575T>A mutation may associate with melanoma and DLBCL and exert a differential effect in different cancer sites. However, other factors may influence the association, and large-scale multicenter with adequate methodological quality studies are needed to confirm the impact on cancer susceptibility.

• Authors: Zhi-Ming Dai, Jie Liu, Xing-Mei Cao, Yang Zhang, Meng Wang, Xing-Han Liu, Chang-Ji Li, Zhi-Jun Dai, Wang-Gang Zhang
• Journal: Genetic testing and molecular biomarkers (Genet Test Mol Biomarkers) Vol. 19 Issue 6 Pg. 324-30 (Jun 2015) ISSN: 1945-0257 [Electronic] United States
• PMID: 25955784 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-10

Topics

• Case-Control Studies
• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• Interleukin-10 (genetics)
• Lymphoma, Large B-Cell, Diffuse (genetics)
• Melanoma (genetics)
• Odds Ratio
• Polymorphism, Single Nucleotide
• Risk Factors