Review on hepatic explant pathology of pediatric intestinal transplant recipients: Is it time for an oil change?

Abstract

A recent study attempts to add to the body of evidence that is emerging regarding the fish oil parenteral lipid product Omegaven™. The authors have shown from explant livers of children on chronic parenteral nutrition with Omegaven™ that biochemical improvement in cholestasis does not always reflect improvement in liver histology. These findings support 2 small case series that were previously published. Despite improvement and resolution of hyperbilirubinemia in all six infants, five of six infants had persistent or progressive hepatic fibrosis, while only one infant had regression of fibrosis. The study raises questions of whether there is a window of opportunity for efficacy of this preparation; also, an important question is if this omega-3 fatty acid-rich preparation is superior to newer "blended lipids" containing olive, coconut, soy, and fish oil.

• Authors: Essam Imseis, J Marc Rhoads
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 21 Issue 17 Pg. 5115-8 (May 07 2015) ISSN: 2219-2840 [Electronic] United States
• PMID: 25954084 (Publication Type: Editorial, Comment)

Chemical References

• Fat Emulsions, Intravenous
• Fish Oils

Topics

• Fat Emulsions, Intravenous
• Female
• Fish Oils (administration & dosage)
• Humans
• Hyperbilirubinemia (therapy)
• Intestinal Diseases (therapy)
• Intestines (transplantation)
• Liver (pathology)
• Liver Cirrhosis (diagnosis)
• Male