Effects of ALE-36 on gastric secretion, and gastric and duodenal ulcers induced in rats.

Abstract

We examined the antisecretory and anti-ulcer effects of ALE-36 in rats. ALE-36 (3-30 mg/kg) dose-dependently inhibited gastric acid secretion in pylorus-ligated rats. However, the agent apparently increased the volume of gastric juice, and the Na+ and Cl- ion outputs. These changes were almost completely prevented by pretreatment with indomethacin, suggesting that endogenous prostaglandins in the gastric mucosa mediated the changes. Pretreatment with ALE-36 (3-30 mg/kg) inhibited the development of stress-, aspirin-, and indomethacin-induced gastric lesions, and mepirizole-induced duodenal ulcers. Repeated administration of ALE-36 significantly accelerated the healing of gastric ulcers induced by thermocautery.

• Authors: T Kyoi, O Yamamoto, Y Ide, F Ueda, K Kimura
• Journal: Scandinavian journal of gastroenterology. Supplement (Scand J Gastroenterol Suppl) Vol. 162 Pg. 182-5 ( 1989) ISSN: 0085-5928 [Print] England
• PMID: 2595293 (Publication Type: Journal Article)

Chemical References

• Benzimidazoles
• Chlorides
• methyl 2-(3,4-dimethoxystyryl)benzimidazole-4-carboxylate
• Sodium
• Indomethacin

Topics

• Animals
• Benzimidazoles (pharmacology, therapeutic use)
• Chlorides (antagonists & inhibitors)
• Dose-Response Relationship, Drug
• Duodenal Ulcer (prevention & control)
• Gastric Juice (metabolism)
• Gastric Mucosa (drug effects, metabolism)
• Indomethacin (pharmacology)
• Male
• Rats
• Rats, Inbred Strains
• Sodium (antagonists & inhibitors)
• Stomach Ulcer (prevention & control)