[Efficacy Analysis of MAC Regimen as Salvage Treatment Protocol for Acute Myeloid Leukemia Patients Older Than 55 Years].

Abstract

OBJECTIVE:

To evaluate the efficacy and safety of MAC regimen in the treatment of acute myeloid leukemia(AML) patients older than 55 years.

METHODS:

A total of 33 relapsed or non-remission AML patients older than 55 years were enrolled in this research. MAC regimen was given as the salvage treatment. Complete remission rate(CR), partial remission rate(PR), overall survival(OS), relapse-free survival(RFS) and adverse effect were analysed.

RESULTS:

CR rate after the salvage therapy with MAC was 51.1%, partial remission (PR) rate was 6.1%, the overall response rate (ORR) was 57.6%, the median OS was 8 months (1.0-66.0 months), the median relapse-free survival (RFS) was 10.1 months (2.3-40.4 months). Mortality related with salvage treatment in 30 days was 9.1%. Low incidence of severe organ damage were found.

CONCLUSION:

MAC can be used as a relative effective and safe regimen for the salvage treatment of the older AML patients.

• Authors: Xing-Li Zhao, Shu-Ning Wei, Kai-Qi Liu, Dong Lin, Hui Wei, Ying Wang, Chun-Lin Zhou, Bing-Cheng Liu, Wei Li, Zeng Cao, Ben-Fa Gong, Yun-Tao Liu, Xiao-Yuan Gong, Yan Li, Run-Xia Gu, Guang-Ji Zhang, Jian-Xiang Wang, Ying-Chang Mi
• Journal: Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 23 Issue 2 Pg. 396-400 (Apr 2015) ISSN: 1009-2137 [Print] China
• PMID: 25948192 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cytarabine
• Chlorambucil
• Dactinomycin
• Methotrexate

Topics

• Antineoplastic Combined Chemotherapy Protocols
• Chlorambucil
• Cytarabine
• Dactinomycin
• Humans
• Leukemia, Myeloid, Acute
• Methotrexate
• Middle Aged
• Recurrence
• Remission Induction
• Salvage Therapy