VALIDATION OF THERAPEUTIC RESPONSE ASSESSMENT BY BONE SCINTIGRAPHY IN PATIENTS WITH BONE-ONLY METASTATIC BREAST CANCERS DURING ZOLEDRONIC ACID TREATMENT: COMPARISON WITH COMPUTED TOMOGRAPHY ASSESSMENT.

Abstract

PURPOSE:

To validate the use of bone scintigraphy (BS) versus computed tomography (CT) for therapeutic monitoring in patients during treatment with zoledronic acid.

MATERIALS AND METHODS:

Eleven patients with bone-only metastatic disease and being treated with zoledronic acid were included. The effects of therapies including chemotherapy and hormone therapy were evaluated in 25 separate examinations in total as follows: complete response (CR), when no bone metastasis was visible; partial response (PR), when a decrease in the lesion area was detected; stable disease (SD), when no or slight change was observed; and progressive disease (PD), when new or enlarged lesion areas were observed.

RESULTS:

The accuracies of examination by Readers 1, 2, and 3 respectively were 76%, 80% and 76% for BS, 52%, 48%, and 40% for CT, and 64%, 52% and 60% for BS and CT combined with Readers 2 and 3 observing significant differences between CT and BS results. The rates of interobserver agreement between Readers 1 and 2, between Readers 1 and 3, and between Reader 2 and 3 respectively, were 84%, 80% and 88% (κ = 0.648, 0.561 and 0.766) for BS, 52%, 56%, and 60% (κ = 0.180, 0.278 and 0.282) for CT, and 52%, 60%, and 56% (κ = 0.215, 0.282 and 0.232) for CT and BS combined.

CONCLUSION:

BS is effective for assessing the response of bone metastasis to therapy in patients during zoledronic acid treatment.

• Authors: Shirou Ishii, Ken Kikuchi, Masayuki Miyajima, Kotaro Sakuma, Fumio Shishido
• Journal: Fukushima journal of medical science (Fukushima J Med Sci) Vol. 61 Issue 1 Pg. 23-31 ( 2015) ISSN: 2185-4610 [Electronic] Japan
• PMID: 25946906 (Publication Type: Comparative Study, Journal Article, Validation Study)

Chemical References

• Bone Density Conservation Agents
• Diphosphonates
• Imidazoles
• Fluorodeoxyglucose F18
• Zoledronic Acid

Topics

• Adult
• Aged
• Bone Density Conservation Agents (therapeutic use)
• Bone Neoplasms (diagnostic imaging, drug therapy, secondary)
• Bone and Bones (diagnostic imaging)
• Breast Neoplasms (pathology)
• Diphosphonates (therapeutic use)
• Female
• Fluorodeoxyglucose F18
• Humans
• Imidazoles (therapeutic use)
• Middle Aged
• Positron-Emission Tomography
• Tomography, X-Ray Computed
• Zoledronic Acid