Spontaneous hepatitis C viral clearance and hepatitis C chronic infection are associated with distinct cytokine profiles in Mexican patients.

Abstract

The mechanisms related to the spontaneous clearance of hepatitis C virus (HCV) have been primarily studied in regions where the infection is endemic. Results of prior studies have been extrapolated to populations with low endemicity, such as Mexico. Herein, we determined the cytokine profiles in serum samples from Mexican patients who spontaneously cleared HCV and patients chronically infected with HCV genotype 1a. Chronic HCV-infected patients displayed increased interleukin (IL)-8 and regulated upon activation, normal T-cell expressed and secreted (CCL-5) secretion, whereas patients who spontaneously cleared HCV showed augmented levels of IL-1 alpha, tumour necrosis factor-alpha, transforming growth factor-beta, monocyte chemoattractant protein-2 (CCL-8), IL-13 and IL-15. Our study suggests that cytokine profiles may predict disease outcome during HCV infection.

• Authors: Nora A Fierro, Karina González-Aldaco, Rafael Torres-Valadez, Maria E Trujillo-Trujillo, Sonia Roman, Jorge L Trujillo-Ochoa, Arturo Panduro
• Journal: Memorias do Instituto Oswaldo Cruz (Mem Inst Oswaldo Cruz) Vol. 110 Issue 2 Pg. 267-71 (Apr 2015) ISSN: 1678-8060 [Electronic] Brazil
• PMID: 25946254 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• RNA, Viral

Topics

• Adult
• Cytokines (blood, immunology)
• Female
• Fibrosis
• Hepacivirus (immunology)
• Hepatitis C, Chronic (immunology)
• Humans
• Immunoblotting
• Liver (virology)
• Male
• Mexico
• Middle Aged
• RNA, Viral (isolation & purification)
• Remission, Spontaneous
• Viral Load (immunology)