Th1 chemokines in ulcerative colitis.

Abstract

Many studies have shown that chemokine (C-X-C motif) receptor (CXCR)3 (a chemokine receptor in the CXC family) and its ligand chemokines, monokine induced by interferon (IFN)-γ(MIG), IFN-γ-inducible protein 10 (IP-10) and IFN-inducible T-cell α chemoattractant (I-TAC), are strongly overexpressed in the intestinal mucosa of mice with experimental colitis, and in patients with ulcerative colitis (UC) both in lymphocytes, in macrophages and in epithelial cells. IFN-γ induces CXCR3 and its chemokines expression in epithelial colonic cells; MIG, IP-10 and I-TAC are important for the recruitment of granulocytes and mononuclear cells and thus for the maintenance of inflammation in UC. Serum IP-10 levels reflected UC disease activity, and it may be a marker for the responsiveness of patients to treatments. Recently, a phase II study suggested that an anti-IP-10 antibody, BMS-936557, is a potentially effective therapy for moderately-to-severely active UC.

• Authors: F Ragusa
• Journal: La Clinica terapeutica (Clin Ter) Vol. 166 Issue 2 Pg. e126-31 ( 2015) ISSN: 1972-6007 [Electronic] Italy
• PMID: 25945446 (Publication Type: Journal Article)

Chemical References

• CXCL10 protein, human
• CXCR3 protein, human
• Chemokine CXCL10
• Chemokine CXCL11
• Chemokine CXCL9
• Receptors, CXCR3
• Interferon-gamma

Topics

• Animals
• Chemokine CXCL10 (blood)
• Chemokine CXCL11 (metabolism)
• Chemokine CXCL9 (metabolism)
• Colitis, Ulcerative (metabolism)
• Epithelial Cells (metabolism)
• Humans
• Interferon-gamma (physiology)
• Intestinal Mucosa (metabolism)
• Leukocytes (metabolism)
• Mice
• Receptors, CXCR3 (metabolism)
• Th1 Cells (metabolism)