The role of skin mast cells (MCs) in wound healing has been extensively investigated. The present study was designed to examine the effect of the aliamide
adelmidrol on MCs during healing of experimental cutaneous
wounds.
Adelmidrol gel or the vehicle alone was applied 3 times daily on 5-mm punch biopsy
wounds created on the thoracolumbar skin of 10 dogs.
Wounds were allowed to heal by secondary intention. Eight-mm punch samples of the healing
wounds were taken on days 1, 2, 4, 8, and 14, for histology. Mast cell numbers were counted and granular content assessed by densitometric analysis on
toluidine blue-stained sections. The overall mean granule content was significantly greater in the treated
wounds compared to control
wounds, whereas no statistically significant differences in MC counts were observed. These data indicate a reduction in MC degranulation in
wounds topically treated with
adelmidrol suggesting that the compound is able to down-modulate skin MC releasability without affecting their number.