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Type 2 diabetic rats on diet supplemented with chromium malate show improved glycometabolism, glycometabolism-related enzyme levels and lipid metabolism.

Abstract
Our previous study showed that chromium malate improved the regulation of blood glucose in mice with alloxan-induced diabetes. The present study was designed to evaluate the effect of chromium malate on glycometabolism, glycometabolism-related enzymes and lipid metabolism in type 2 diabetic rats. Our results showed that fasting blood glucose, serum insulin level, insulin resistance index and C-peptide level in the high dose group had a significant downward trend when compared with the model group, chromium picolinate group and chromium trichloride group. The hepatic glycogen, glucose-6-phosphate dehydrogenase, glucokinase, Glut4, phosphor-AMPKβ1 and Akt levels in the high dose group were significantly higher than those of the model, chromium picolinate and chromium trichloride groups. Chromium malate in a high dose group can significantly increase high density lipoprotein cholesterol level while decreasing the total cholesterol, low density lipoprotein cholesterol and triglyceride levels when compared with chromium picolinate and chromium trichloride. The serum chromium content in chromium malate and chromium picolinate group is significantly higher than that of the chromium trichloride group. The results indicated that the curative effects of chromium malate on glycometabolism, glycometabolism-related enzymes and lipid metabolism changes are better than those of chromium picolinate and chromium trichloride. Chromium malate contributes to glucose uptake and transport in order to improved glycometabolism and glycometabolism-related enzymes.
AuthorsWeiwei Feng, Ting Zhao, Guanghua Mao, Wei Wang, Yun Feng, Fang Li, Daheng Zheng, Huiyu Wu, Dun Jin, Liuqing Yang, Xiangyang Wu
JournalPloS one (PLoS One) Vol. 10 Issue 5 Pg. e0125952 ( 2015) ISSN: 1932-6203 [Electronic] United States
PMID25942313 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Blood Glucose
  • Insulin
  • Malates
  • Chromium
  • malic acid
  • Glycogen
  • Glucose
Topics
  • Animals
  • Biological Transport
  • Blood Glucose
  • Body Weight
  • Chromium (pharmacology)
  • Diabetes Mellitus, Experimental
  • Diabetes Mellitus, Type 2 (enzymology, metabolism)
  • Dietary Supplements
  • Disease Models, Animal
  • Fasting
  • Gastrointestinal Microbiome (drug effects)
  • Glucose (metabolism)
  • Glycogen (metabolism)
  • Insulin (blood)
  • Lipid Metabolism
  • Liver (drug effects, metabolism, microbiology)
  • Malates (pharmacology)
  • Male
  • Maze Learning
  • Rats

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