Development of a New Magnetometer for Sentinel Lymph Node Mapping Designed for Video-Assisted Thoracic Surgery in Non-Small Cell Lung Cancer.

Abstract

BACKGROUND:

We previously developed a method for sentinel lymph node (SLN) mapping in non-small cell lung cancer (NSCLC), based on the magnetic force produced by a magnetite tracer already approved for use as a contrast material for magnetic resonance imaging. However, it is difficult to use that technique with video-assisted thoracic surgery (VATS) because the sensing element of the magnetometer is large and thick. The purpose of the present study was to develop a smaller, thinner VATS-compatible magnetometer.

METHODS:

The tracer employed was Ferucarbotran, a colloidal solution of superparamagnetic iron oxide coated with carbodextran. Fifteen patients with clinical stage I NSCLC were enrolled, and each received 1.6 mL of Ferucarbotran, injected intraoperatively at 5 points around the tumor. The magnetic force within the sampling lymph nodes was measured using the new VATS-compatible magnetometer.

RESULTS:

SLNs were detected in 11 (73.3%) of the 15 patients using the VATS-compatible magnetometer. The average number of SLNs identified per patient was 1.8 (range 0-4). No complications related to the SLN detection method were observed.

CONCLUSIONS:

The new VATS-compatible magnetometer appears to have substantial advantages over techniques using a radioisotope and our earlier magnetometer, as it can be inserted through the small VATS port site.

• Authors: Kazuhiro Imai, Yasushi Kawaharada, Jun-Ichi Ogawa, Hajime Saito, Satoshi Kudo, Shinogu Takashima, Yoshitaro Saito, Maiko Atari, Aki Ito, Kaori Terata, Kei Yoshino, Yusuke Sato, Satoru Motoyama, Yoshihiro Minamiya
• Journal: Surgical innovation (Surg Innov) Vol. 22 Issue 4 Pg. 401-5 (Aug 2015) ISSN: 1553-3514 [Electronic] United States
• PMID: 25940853 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2015.

Chemical References

• Ferrosoferric Oxide

Topics

• Aged
• Carcinoma, Non-Small-Cell Lung (surgery)
• Equipment Design
• Ferrosoferric Oxide (therapeutic use)
• Humans
• Lung Neoplasms (surgery)
• Magnetometry (instrumentation)
• Middle Aged
• Sentinel Lymph Node Biopsy (instrumentation, methods)
• Thoracic Surgery, Video-Assisted (instrumentation)