Abstract | BACKGROUNDS: METHODS: We performed [(18)F] FP-CIT positron emission tomography studies in 42 consecutive parkinsonian patients with diffuse leukoaraiosis, but no basal ganglia vascular lesions. RESULTS: Twenty (48%) of the 42 patients had coexisting NDD. Compared to parkinsonian patients with isolated leukoaraiosis, those with coexisting NDD more frequently had asymmetric onset. They had similar degree of parkinsonian motor deficits in the legs, but greater rigidity and resting tremor in the arms. Consequently, they had less prominent lower body parkinsonism. They more frequently showed favorable response to levodopa treatment. They had similar burden of regional and total leukoaraiosis. Among a variety of clinical variables and MRI findings, only asymmetric onset and more than 30% improvement in UPDRS motor score by levodopa treatment were valuable indicators of coexisting NDD. CONCLUSIONS: We would like to recommend dopaminergic functional imaging studies for all parkinsonian patients with leukoaraiosis. Further studies are needed to confirm sensitivity and specificity of asymmetric onset and good levodopa response for the prediction of coexisting NDD in a different group of parkinsonian patients with leukoaraiosis.
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Authors | M J Lee, S L Kim, H I Kim, Y J Oh, S H Lee, H K Kim, C S Han, C H Lyoo, Y H Ryu, M S Lee |
Journal | Parkinsonism & related disorders
(Parkinsonism Relat Disord)
Vol. 21
Issue 7
Pg. 704-8
(Jul 2015)
ISSN: 1873-5126 [Electronic] England |
PMID | 25937616
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Corpus Striatum
(diagnostic imaging)
- Female
- Fluorine Radioisotopes
- Humans
- Leukoaraiosis
(diagnostic imaging, epidemiology)
- Male
- Parkinsonian Disorders
(diagnostic imaging, epidemiology)
- Positron-Emission Tomography
(methods)
- Substantia Nigra
(diagnostic imaging)
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