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Surgical attenuation of spontaneous congenital portosystemic shunts in dogs resolves hepatic encephalopathy but not hypermanganesemia.

Abstract
Hypermanganesemia is commonly recognized in human patients with hepatic insufficiency and portosystemic shunting. Since manganese is neurotoxic, increases in brain manganese concentrations have been implicated in the development of hepatic encephalopathy although a direct causative role has yet to be demonstrated. Evaluate manganese concentrations in dogs with a naturally occurring congenital shunt before and after attenuation as well as longitudinally following the changes in hepatic encephalopathy grade. Our study demonstrated that attenuation of the shunt resolved encephalopathy, significantly reduced postprandial bile acids, yet a hypermanganasemic state persisted. This study demonstrates that resolution of hepatic encephalopathy can occur without the correction of hypermanganesemia, indicating that increased manganese concentrations alone do not play a causative role in encephalopathy. Our study further demonstrates the value of the canine congenital portosystemic shunt as a naturally occurring spontaneous model of human hepatic encephalopathy.
AuthorsAdam G Gow, Polly E Frowde, Clive M Elwood, Carolyn A Burton, Roger M Powell, Simon W Tappin, Rob D Foale, Andrew Duncan, Richard J Mellanby
JournalMetabolic brain disease (Metab Brain Dis) Vol. 30 Issue 5 Pg. 1285-9 (Oct 2015) ISSN: 1573-7365 [Electronic] United States
PMID25936718 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

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