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Application of plasma clearance of iohexol in evaluating renal function in chinese children with chronic kidney disease.

AbstractOBJECTIVE:
To evaluate the accuracy of plasma clearance of iohexol (PCio) for glomerular filtration rate (GFR) measurement in Chinese children with chronic kidney disease (CKD) and assess the feasibility of single-blood-sample method or dried capillary blood spots in determining the PCio.
METHODS:
Totally 45 CKD children were included,in whom the (99m) Technetium-diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) plasma clearance and iohexol plasma clearance were simultaneously determined. Blood samples were obtained 2,4,and 5 hours after injection. In addition, we also evaluated the efficacy of single blood sample method and dried blood spots method in iohexol plasma clearance.
RESULTS:
Forty-five CKD children completed the iohexol plasma clearance and thirty-six children completed the (99m)Tc-DTPA plasma clearance at the same time among them. Thirteen children finished the iohexol dried blood spot clearance. The correlation coefficient between (99m)Tc-DTPA plasma clearance and iohexol plasma clearance was 0.941 and the bias was (6.53 ± 11.6) ml/ (min·1.73 m²), and the intraclass correlation coefficient (ICC) was high (ICC=0.947). The correlation between iohexol single-sample plasma clearance and double samples was also strong (r=0.958), with the bias being (4.26 ± 9.06)ml/(min·1.73 m²) and the ICC being 0.970. The iohexol clearance by dried blood spots showed a good correlation with the serum iohexol clearance (r=0.950), with the bias still being small [(0.48 ± 10.89)ml/(min·1.73 m²)].
CONCLUSIONS:
Iohexol plasma clearance has satisfactory agreement with (99m)Tc-DTPA plasma clearance and can be used as an ideal method to measure GFR in CKD children. The single-sample method and dried blood spots method make iohexol plasma clearance more convenient and practical.
AuthorsBao-bao Wang, Yuan Wu, Yan Qin, Meng-chun Gong, Xi-min Shi, Hong-li Jing, Fang Li, Chao-ying Chen, Hong-mei Song, Xue-mei Li
JournalZhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao) Vol. 37 Issue 2 Pg. 171-8 (Apr 2015) ISSN: 1000-503X [Print] China
PMID25936705 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Iohexol
  • Technetium Tc 99m Pentetate
Topics
  • Child
  • Glomerular Filtration Rate
  • Humans
  • Iohexol
  • Renal Insufficiency, Chronic
  • Technetium Tc 99m Pentetate

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