Abstract | BACKGROUND: METHODS: We used data from an Italian case-control study including 230 patients with incident, histologically confirmed gastric cancer, and 547 frequency matched controls admitted to the same hospitals for acute non-neoplastic diseases. A reproducible and valid food frequency questionnaire was used to assess subjects' usual diet. NEAC was measured using Italian food composition tables in terms of Trolox equivalent antioxidant capacity (TEAC), Ferric reducing- antioxidant power (FRAP) and Total radical-trapping antioxidant parameter (TRAP). We estimated the odds ratios (OR) of gastric cancer and the corresponding 95% confidence intervals (CI) using conditional logistic regression models including terms for recognized gastric cancer risk factors and total energy intake. RESULTS: NEAC was inversely related with gastric cancer risk with ORs for the highest versus the lowest quintile of 0.54 (95%CI, 0.33-0.88) for TEAC, 0.67 (95%CI, 0.42-1.07) for FRAP and 0.57 (95%CI, 0.36-0.90) for TRAP. CONCLUSIONS: A diet rich in antioxidant capacity reduced gastric cancer risk, suggesting a high consumption of fruit and vegetables and a moderate consumption of wine and whole cereals.
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Authors | Delphine Praud, Maria Parpinel, Mauro Serafini, Rino Bellocco, Alessandra Tavani, Pagona Lagiou, Carlo La Vecchia, Marta Rossi |
Journal | Cancer epidemiology
(Cancer Epidemiol)
Vol. 39
Issue 3
Pg. 340-5
(Jun 2015)
ISSN: 1877-783X [Electronic] Netherlands |
PMID | 25936460
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Aged
- Antioxidants
- Case-Control Studies
- Diet
- Edible Grain
- Female
- Fruit
- Humans
- Logistic Models
- Male
- Middle Aged
- Odds Ratio
- Risk Factors
- Stomach Neoplasms
(epidemiology)
- Vegetables
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