Abstract | BACKGROUND: METHODS: Blood samples from 58 patients with TS and 128 age-matched healthy controls enabled measurement of antistreptolysin O (ASO), T cells, natural killer (NK) cells, interleukin-6 (IL-6) and interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α). Forty-four patients with abnormal T cell numbers were divided into two groups and treated with pidotimod granules ( pidotimod group, n = 20) or pidotimod plus dopaminergic receptor antagonists (combination group, n = 24). Yale Global Tic Severity Scale (YGTSS) scores and immunologic indices were assessed after treatment. RESULTS: An ASO >1:200 was found in 22.4% of children with TS, 7.5% of controls, and 38.9% of children with both TS and attention deficit hyperactivity disorder ( ADHD) compared to 15.0% of children with TS alone (P < 0.05). Children with TS showed decreased CD3(+) and CD4(+) T cells, CD4(+)/CD8(+) ratio, IL-6 and IL-8, increased NKC and TNF-α (P < 0.05) as compared to controls. ASO-positive children with TS had lower CD4(+) T cells as compared to ASO-negative children with TS, and lower IL-6 and IL-8 levels as compared to controls (P < 0.05). After 8 weeks of pidotimod treatment, IL-8 was increased compared to either tiapride hydrochloride or haloperidol and pidotimod (P < 0.05). CONCLUSIONS:
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Authors | Erzhen Li, Yiyan Ruan, Qian Chen, Xiaodai Cui, Lingyun Lv, Ping Zheng, Liwen Wang |
Journal | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
(Childs Nerv Syst)
Vol. 31
Issue 7
Pg. 1157-63
(Jul 2015)
ISSN: 1433-0350 [Electronic] Germany |
PMID | 25930720
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Case-Control Studies
- Child
- Child, Preschool
- Cytokines
(metabolism)
- Female
- Follow-Up Studies
- Humans
- Male
- Retrospective Studies
- Severity of Illness Index
- Streptococcal Infections
(etiology)
- T-Lymphocytes
(metabolism, pathology)
- Tourette Syndrome
(complications, immunology, therapy)
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