Physiological relevance of food grade microcapsules: Impact of milk protein based microcapsules on inflammation in mouse models for inflammatory bowel diseases.

Abstract

In order to increase beneficial effects of bioactive compounds in functional food and dietary supplements, enormous efforts are put in the technological development of microcapsules. Although these products are often tailor-made for disease susceptible consumer, the physiological impact of microcapsule uptake on the respective target consumer has never been addressed. The present study aimed to assess the relevance of this aspect by analyzing the impact of milk protein based microcapsules on experimental inflammatory bowel disease. Long-term feeding of sodium caseinate or rennet gel microcapsules resulted in significant alterations in the intestinal microbiota of healthy mice. In TNFΔARE/wt mice, a model for chronic ileal inflammation, rennet gel microcapsules resulted in further increased splenomegaly, whereas ileal inflammation was unchanged. In IL10(-/-) mice, a model for chronic colitis, both types of microcapsules induced a local increase of the intestinal inflammation. The present study is the first to demonstrate that, independent of their cargo, microcapsules have the potential to affect the intestinal microbiota and to exert unprecedented detrimental effects on disease-susceptible individuals. In conclusion, the impact of microcapsule uptake on the respective target consumer groups should be thoroughly investigated in advance to their commercial use in functional food or dietary supplements.

• Authors: Rebecca Würth, Ilias Lagkouvardos, Thomas Clavel, Julia Wilke, Petra Foerst, Ulrich Kulozik, Dirk Haller, Gabriele Hörmannsperger
• Journal: Molecular nutrition & food research (Mol Nutr Food Res) Vol. 59 Issue 8 Pg. 1629-34 (Aug 2015) ISSN: 1613-4133 [Electronic] Germany
• PMID: 25929669 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Capsules
• Caseins
• Gels
• Inflammation Mediators
• Milk Proteins
• rennet
• Chymosin

Topics

• Animals
• Capsules
• Caseins (adverse effects, chemistry)
• Chymosin (adverse effects, chemistry)
• Colitis (blood, diet therapy, microbiology, physiopathology)
• Dietary Supplements (adverse effects)
• Disease Models, Animal
• Female
• Gastrointestinal Microbiome
• Gels
• Ileitis (blood, diet therapy, microbiology, physiopathology)
• Inflammation Mediators (blood)
• Inflammatory Bowel Diseases (blood, diet therapy, microbiology, physiopathology)
• Male
• Mice, Inbred Strains
• Mice, Knockout
• Mice, Mutant Strains
• Milk Proteins (administration & dosage, adverse effects, therapeutic use)
• Severity of Illness Index
• Splenomegaly (etiology)