Abstract | BACKGROUND: METHODS: Sixty two patients undergoing thyroidectomy under general anesthesia were randomly allocated into two groups. All patients were anesthetised with desflurane and high-dose remifentanil. Remifentnail was infused at the rate of 0.3 μg/kg/min until the end of surgery in patients of the control group (group A) whereas remifentanil was tapered gradually from 0.3 to 0.1 μg/kg/min until the end of surgery for at least 30 minutes in patients with group B. Pain scores (0-100 numerical rating scale, NRS), rescue analgesic requirements and adverse events were assessed at 30 min, 2 h, 6 h, 12 h, and 24 h after operation. RESULTS: There was a significant decrease in pain scores at 30 min (20 [0-80] vs. 50 [0-100], P = 0.002) and 2 h (30 [10-60] vs. 40 [20-80], P = 0.018) after surgery in group B compared with group A. In addition, rescue analgesics are less required in group B than in group A postoperatively (2 [1-3] vs. 3 [2,3], P = 0.039). There were no significant differences in adverse events between the two groups. CONCLUSIONS: TRIAL REGISTRATION: Clinical Research information Service (CRiS, registration number KCT0000589).
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Authors | Sun Sook Han, Sang Hwan Do, Tae Hee Kim, Won Joon Choi, Ji Sup Yun, Jung Hee Ryu |
Journal | BMC anesthesiology
(BMC Anesthesiol)
Vol. 15
Pg. 46
(Apr 08 2015)
ISSN: 1471-2253 [Electronic] England |
PMID | 25927221
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics
- Anesthetics, Combined
- Anesthetics, Inhalation
- Anesthetics, Intravenous
- Piperidines
- Desflurane
- Isoflurane
- Remifentanil
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Topics |
- Adult
- Aged
- Analgesics
(therapeutic use)
- Anesthesia Recovery Period
- Anesthetics, Combined
(administration & dosage)
- Anesthetics, Inhalation
(administration & dosage)
- Anesthetics, Intravenous
(administration & dosage)
- Desflurane
- Female
- Humans
- Infusions, Intravenous
- Isoflurane
(administration & dosage, analogs & derivatives)
- Male
- Middle Aged
- Pain Measurement
- Pain, Postoperative
(prevention & control)
- Piperidines
(administration & dosage)
- Prospective Studies
- Remifentanil
- Single-Blind Method
- Thyroid Neoplasms
(surgery)
- Thyroid Nodule
(surgery)
- Thyroidectomy
(methods)
- Young Adult
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