Properties and clinical utility of topotecan fluorescence: uses for retinoblastoma.

Abstract

Topotecan fluoresces when exposed to ultraviolet (UV) light. Our observations with UV light in retinoblastoma cases has allowed us to minimise and manage inadvertent skin contact, guide periocular injections and leakage from such injections and document conjunctival contact after periocular injection in addition to demonstrating the drug in the vitreous after intravitreal injection. The technique is safe, inexpensive and easy to perform.

• Authors: Jasmine H Francis, Brian P Marr, Paula Schaiquevich, Michael G Kellick, David H Abramson
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 99 Issue 10 Pg. 1320-2 (Oct 2015) ISSN: 1468-2079 [Electronic] England
• PMID: 25926516 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Chemical References

• Topoisomerase I Inhibitors
• Topotecan

Topics

• Fluorescein Angiography (methods)
• Fundus Oculi
• Humans
• Intravitreal Injections
• Retinal Neoplasms (diagnosis, drug therapy)
• Retinoblastoma (diagnosis, drug therapy)
• Topoisomerase I Inhibitors (administration & dosage)
• Topotecan (administration & dosage)
• Vitreous Body (pathology)