Anti-proliferative activity of hop-derived prenylflavonoids against human cancer cell lines.

Abstract	Flavonoids form a substantial group of secondary plant metabolites that display several health-promoting effects. Therefore, prenylflavonoids, a subclass of flavonoids, have attracted increasing attention. Here, we investigated the possible anti-cancer potential of 6-prenylnaringenin (6-PN) and 8-prenylnaringenin (8-PN), two prenylflavonoids present in hops and beer and demonstrate an unexpectedly pronounced, dose-dependent reduction of cellular proliferation of human PC-3 prostate cancer and UO.31 renal carcinoma cells upon treatment. Based on these findings 6-PN and 8-PN are currently further clinically evaluated in detail.
Authors	Christian Busch, Seema Noor, Christian Leischner, Markus Burkard, Ulrich M Lauer, Sascha Venturelli
Journal	Wiener medizinische Wochenschrift (1946) (Wien Med Wochenschr) Vol. 165 Issue 11-12 Pg. 258-61 (Jun 2015) ISSN: 1563-258X [Electronic] Austria
PMID	25925225 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References	6-prenylnaringenin 8-prenylnaringenin Antineoplastic Agents Flavanones Flavonoids
Topics	Antineoplastic Agents (pharmacology) Cell Line, Tumor Cell Proliferation (drug effects) Dose-Response Relationship, Drug Flavanones (pharmacology) Flavonoids (pharmacology) Humans Humulus Phytotherapy Tumor Cells, Cultured (drug effects)

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