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[Correlation of fractional exhaled nitric oxide with peripheral blood eosinophils and lung function in 1-3-year-old children with asthma].

AbstractOBJECTIVE:
To examine fractional exhaled nitric oxide (FeNO) values in 1-3-year-old children with asthma and analyze the correlation of FeNO with peripheral blood eosinophils (EOS) and lung function in these children.
METHODS:
A total of 111 children aged 1-3 years with asthma were enrolled. The children were classified into acute exacerbation (n=62) and remission groups (n=49) according to their symptoms. FeNO values, lung function, and peripheral blood EOS count were measured in these children. Sixty age-matched healthy children were enrolled as the control group.
RESULTS:
FeNO values were significantly higher in the acute exacerbation group (24.4 ppb) than in the remission group (18.0 ppb) and the control group (13.7 ppb) (P<0.05). The FeNO values in the remission group were significantly higher than in the control group (P<0.05). FeNO values were not significantly correlated with peripheral blood EOS count and lung function parameters (PEF, TEF25, TEF50, and TEF75).
CONCLUSIONS:
Measurement of FeNO is useful to evaluate the disease activity in children with asthma aged 1 to 3 years, but the FeNO values are not correlated with peripheral blood EOS count and lung function.
AuthorsWen-Qiu Tian, Shu-Hua An, Jin-Ying Li
JournalZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics (Zhongguo Dang Dai Er Ke Za Zhi) Vol. 17 Issue 4 Pg. 317-20 (Apr 2015) ISSN: 1008-8830 [Print] China
PMID25919547 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Nitric Oxide
Topics
  • Asthma (blood, physiopathology)
  • Breath Tests
  • Child, Preschool
  • Eosinophils (physiology)
  • Female
  • Humans
  • Infant
  • Lung (physiopathology)
  • Male
  • Nitric Oxide (metabolism)

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