Abstract | OBJECTIVES: In a large cohort of children with intestinal failure (IF), we sought to determine the cumulative incidence of achieving enteral autonomy and identify patient and institutional characteristics associated with enteral autonomy. STUDY DESIGN: RESULTS: A total of 272 infants were followed for a median (IQR) of 33.5 (16.2-51.5) months. Enteral autonomy was achieved in 118 (43%); 36 (13%) remained PN dependent and 118 (43%) patients died or underwent transplantation. Multivariable analysis identified necrotizing enterocolitis (NEC; OR 2.42, 95% CI 1.33-4.47), care at an IF site without an associated intestinal transplantation program (OR 2.73, 95% CI 1.56-4.78), and an intact ileocecal valve (OR 2.80, 95% CI 1.63-4.83) as independent risk factors for enteral autonomy. A second model (n = 144) that included only patients with intraoperatively measured residual small bowel length found NEC (OR 3.44, 95% CI 1.36-8.71), care at a nonintestinal transplantation center (OR 6.56, 95% CI 2.53-16.98), and residual small bowel length (OR 1.04 cm, 95% CI 1.02-1.06 cm) to be independently associated with enteral autonomy. CONCLUSIONS: A substantial proportion of infants with IF can achieve enteral autonomy. Underlying NEC, preserved ileocecal valve, and longer bowel length are associated with achieving enteral autonomy. It is likely that variations in institutional practices and referral patterns also affect outcomes in children with IF.
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Authors | Faraz A Khan, Robert H Squires, Heather J Litman, Jane Balint, Beth A Carter, Jeremy G Fisher, Simon P Horslen, Tom Jaksic, Samuel Kocoshis, J Andres Martinez, David Mercer, Susan Rhee, Jeffrey A Rudolph, Jason Soden, Debra Sudan, Riccardo A Superina, Daniel H Teitelbaum, Robert Venick, Paul W Wales, Christopher Duggan, Pediatric Intestinal Failure Consortium |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 167
Issue 1
Pg. 29-34.e1
(Jul 2015)
ISSN: 1097-6833 [Electronic] United States |
PMID | 25917765
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Topics |
- Canada
(epidemiology)
- Child, Preschool
- Cohort Studies
- Enterocolitis, Necrotizing
(epidemiology)
- Female
- Follow-Up Studies
- Humans
- Ileocecal Valve
- Infant
- Infant, Newborn
- Intestinal Diseases
(epidemiology, therapy)
- Intestines
(transplantation)
- Male
- Multivariate Analysis
- Parenteral Nutrition
- Retrospective Studies
- Risk Factors
- United States
(epidemiology)
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