Abstract |
A hallmark of CpG islands is their unmethylated state, and determining how DNA methylation can invade these elements is therefore important for understanding developmental gene regulation and disease. A new study shows that FBXL10, a protein commonly altered by mutation in leukemia, is part of a mechanism that blocks methylation of CpG islands.
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Authors | Gavin Kelsey |
Journal | Nature genetics
(Nat Genet)
Vol. 47
Issue 5
Pg. 427-8
(May 2015)
ISSN: 1546-1718 [Electronic] United States |
PMID | 25916897
(Publication Type: Journal Article, Comment)
|
Chemical References |
- F-Box Proteins
- Polycomb-Group Proteins
- Jumonji Domain-Containing Histone Demethylases
|
Topics |
- Animals
- DNA Methylation
- F-Box Proteins
(physiology)
- Jumonji Domain-Containing Histone Demethylases
(physiology)
- Male
- Polycomb-Group Proteins
(metabolism)
- Promoter Regions, Genetic
|