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Keeping methylation at bay.

Abstract
A hallmark of CpG islands is their unmethylated state, and determining how DNA methylation can invade these elements is therefore important for understanding developmental gene regulation and disease. A new study shows that FBXL10, a protein commonly altered by mutation in leukemia, is part of a mechanism that blocks methylation of CpG islands.
AuthorsGavin Kelsey
JournalNature genetics (Nat Genet) Vol. 47 Issue 5 Pg. 427-8 (May 2015) ISSN: 1546-1718 [Electronic] United States
PMID25916897 (Publication Type: Journal Article, Comment)
Chemical References
  • F-Box Proteins
  • Polycomb-Group Proteins
  • Jumonji Domain-Containing Histone Demethylases
Topics
  • Animals
  • DNA Methylation
  • F-Box Proteins (physiology)
  • Jumonji Domain-Containing Histone Demethylases (physiology)
  • Male
  • Polycomb-Group Proteins (metabolism)
  • Promoter Regions, Genetic

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