Abstract | OBJECTIVES: METHODS: RESULTS: WFA(+)-M2BP was independently associated with liver fibrosis stage as determined by liver biopsy. The cutoff values of WFA(+)-M2BP for fibrosis stages ≥F1, ≥F2, ≥F3, and F4 were 0.7, 1.0, 1.4, and 2.0, respectively. The area under the receiver operating characteristic curve values for significant fibrosis, severe fibrosis, and cirrhosis were 0.979, 0.933, and 0.965, respectively. WFA(+)-M2BP was significantly superior to the other indices for the determination of significant and severe fibrosis stages. Furthermore, the WFA(+)-M2BP level at enrollment was strongly and independently associated with clinical outcome (hazard ratio 18.59, P=0.021). CONCLUSIONS: Baseline measurements of WFA(+)-M2BP represent a simple and reliable noninvasive surrogate marker of liver fibrosis and prognosis in patients with PBC.
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Authors | Takeji Umemura, Satoru Joshita, Tomohiro Sekiguchi, Yoko Usami, Soichiro Shibata, Takefumi Kimura, Michiharu Komatsu, Akihiro Matsumoto, Masao Ota, Eiji Tanaka |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 110
Issue 6
Pg. 857-64
(Jun 2015)
ISSN: 1572-0241 [Electronic] United States |
PMID | 25916223
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, Neoplasm
- Cholagogues and Choleretics
- Membrane Glycoproteins
- Plant Lectins
- Receptors, N-Acetylglucosamine
- TAA90K protein, human
- wisteria lectin
- Ursodeoxycholic Acid
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Topics |
- Antigens, Neoplasm
(blood)
- Case-Control Studies
- Cholagogues and Choleretics
(therapeutic use)
- Cohort Studies
- Disease Progression
- Female
- Humans
- Liver Cirrhosis
(blood, etiology, pathology)
- Liver Cirrhosis, Biliary
(blood, complications, drug therapy)
- Male
- Membrane Glycoproteins
(blood)
- Middle Aged
- Plant Lectins
- Prognosis
- Proportional Hazards Models
- Receptors, N-Acetylglucosamine
- Retrospective Studies
- Ursodeoxycholic Acid
(therapeutic use)
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