Effects of AGBL2 on cell proliferation and chemotherapy resistance of gastric cancer.

Abstract

BACKGROUND/AIMS:

The present study aimed to investigate the expression status of AGBL2 and its inhibitor latexin, and elucidate their clinical implications in gastric cancer.

METHODOLOGY:

AGBL2 expression status was examined in gastric cancer cells and 256 gastric cancer specimens by immunohistochemistry staining. The relationship between AGBL2 protein expression and clinicopathological parameters and prognosis was subsequently determined.

RESULTS:

AGBL2 expression was determined to be related to pathological tumor and nodal stages by Spearman's regression correlation analysis. The Cox regression test identified AGBL2 protein expression as an independent prognostic factor. AGBL2 and latexin were- found to be related to proliferation and chemotherapy resistance. The 2 proteins also formed immune com- plexes in immunoprecipitation experiments.

CONCLUSIONS:

Our results demonstrate that AGBL2 interacts with latexin, regulating the tubulin tyrosination cycle. It is therefore a potential target for intervention.

• Authors: Haitao Zhu, Zhichao Zheng, Jianjun Zhang, Xiaoping Liu, Yang Liu, Wei Yang, Yong Liu, Tao Zhang, Yan Zhao, Yanqing Liu, Xiaohui Su, Xiaohu Gu
• Journal: Hepato-gastroenterology (Hepatogastroenterology) 2015 Mar-Apr Vol. 62 Issue 138 Pg. 497-502 ISSN: 0172-6390 [Print] Greece
• PMID: 25916089 (Publication Type: Journal Article)

Chemical References

• Antigens
• Antineoplastic Agents
• Biomarkers, Tumor
• Lxn protein, rat
• Carboxypeptidases
• AGBL2 protein, human

Topics

• Antigens (metabolism)
• Antineoplastic Agents (therapeutic use)
• Biomarkers, Tumor (genetics, metabolism)
• Carboxypeptidases (genetics, metabolism)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Drug Resistance, Neoplasm
• Female
• Gastrectomy
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Molecular Targeted Therapy
• Multivariate Analysis
• Neoplasm Staging
• Proportional Hazards Models
• RNA Interference
• Risk Factors
• Signal Transduction
• Stomach Neoplasms (genetics, immunology, metabolism, mortality, pathology, therapy)
• Time Factors
• Transfection
• Treatment Outcome