Seroprotection after hepatitis B vaccination in children aged 1 to 15 years in central province of Iran, Semnan.

Abstract

INTRODUCTION:

There are controversies over the long-term persistence of post vaccination immunity to hepatitis B and the need for booster doses of the vaccine. The aim of this study was to verify antibody levels of antibody against hepatitis B virus surface antigen (anti-HBs) in children aged 1 to 15 years who received vaccination against hepatitis B in the central province of Iran, Semnan.

MATERIALS AND METHODS:

We performed a seroepidemiological survey (n = 210) of anti-HBs in 2011 in the central province of Iran, Semnan using enzyme-linked immunosorbent assay (ELISA). The levels of anti-HBs < 10 mIU/mL were considered to be negative and samples showing an anti-HBs titer ≥ 10 mIU/mL was considered protective.

RESULTS:

Protective antibody levels were detected in 88% of the children less than 5 year after vaccination, decreased to 78% between 5 to 10 years after vaccination, and further declined to 74% in 10 years after vaccination, respectively.

CONCLUSION:

The vaccination program has been proven effective in Semnan and immunological protection against hepatitis B infection was found in the majority of children even more than 10 years after being vaccinated.

• Authors: M Rezaei, S Nooripoor, R Ghorbani, F Ramezanshams, S Mamishi, S Mahmoudi
• Journal: Journal of preventive medicine and hygiene (J Prev Med Hyg) Vol. 55 Issue 1 Pg. 1-3 (Mar 2014) ISSN: 1121-2233 [Print] Italy
• PMID: 25916024 (Publication Type: Journal Article)

Chemical References

• Hepatitis B Antibodies
• Hepatitis B Surface Antigens
• Hepatitis B Vaccines

Topics

• Adolescent
• Child
• Child, Preschool
• Cross-Sectional Studies
• Enzyme-Linked Immunosorbent Assay
• Female
• Hepatitis B (immunology, prevention & control)
• Hepatitis B Antibodies (immunology)
• Hepatitis B Surface Antigens (immunology)
• Hepatitis B Vaccines (immunology, therapeutic use)
• Hepatitis B virus (immunology)
• Humans
• Infant
• Iran
• Male
• Time Factors