Double-blind plethysmographic study of venous effects of heptaminol adenosine phosphate in patients with primary varicose veins.

Abstract

Changes in venous haemodynamics were studied after administration of a single dose of 3 g Heptaminol Adenosine Phosphate (HAP) to 30 subjects with primary varicose veins. Strain gauge plethysmography was used to observe changes in venous volume and in maximal venous outflow, 1, 2, 3 and 4 h after dosing. A significantly greater reduction in these parameters was found after treatment with HAP compared to placebo, indicating an improvement in lower limb venous circulation.

• Authors: C Schmidt, R Gavoille, P Perez, J Schmitt
• Journal: European journal of clinical pharmacology (Eur J Clin Pharmacol) Vol. 37 Issue 1 Pg. 37-40 ( 1989) ISSN: 0031-6970 [Print] Germany
• PMID: 2591460 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Amino Alcohols
• Heptaminol
• Adenosine Monophosphate
• heptaminol AMP amidate

Topics

• Adenosine Monophosphate (analogs & derivatives, therapeutic use)
• Amino Alcohols (therapeutic use)
• Double-Blind Method
• Female
• Heptaminol (analogs & derivatives, therapeutic use)
• Humans
• Leg (blood supply)
• Male
• Middle Aged
• Plethysmography
• Regional Blood Flow (drug effects)
• Time Factors
• Varicose Veins (drug therapy, physiopathology)