Abstract | BACKGROUND: METHODS: This prospective single-center observational study was undertaken in a UK General Hospital emergency department. We recruited consecutive adults with chest pain and a nondiagnostic electrocardiogram, for whom the treating physician determined that delayed troponin testing was necessary. Using their own clinical judgment, physicians recorded whether the chest pain described was typical or atypical for acute coronary syndrome. Physicians were defined as "experienced" or "novice" according to postgraduate experience. Acute myocardial infarction was adjudicated using a high-sensitivity troponin (hs- cTn) assay, whereas coronary artery disease was adjudicated angiographically. RESULTS: Overall, 912 patients had typicality of chest pain assessed, of whom 114/912 (12.5%) had an acute myocardial infarction and 157/912 (17.2%) underwent angiography. In patients undergoing angiography, 90/157 (57.3%) had hs- cTn elevation, of whom 60 (66.7%) had significant coronary artery disease. Sixty-seven of 157 (42.7%) patients had angiography without hs- cTn elevation; of these, 31 (46.2%) had significant coronary artery disease. For the diagnosis of acute myocardial infarction, chest pain typicality had an area under the curve (AUC) of 0.54 (95% confidence interval [CI], 0.49-0.60). For the prediction of significant coronary artery disease with hs- cTn elevation AUC: 0.54 (95% CI, 0.40-0.67), and without hs- cTn elevation AUC: 0.45 (95% CI, 0.31-0.59). When assessed by experienced physicians, specificity for the diagnosis of acute myocardial infarction was higher at 65.8% (95% CI, 63.1%-68.7%) vs 55.4% (95% CI, 53.9%-56.8%) for novices. CONCLUSIONS: Subjective interpretation of "typicality of chest pain" is of limited discriminatory value in the assessment of suspected acute coronary syndromes, in the context of a nondiagnostic electrocardiogram. Greater clinical experience improves accuracy as a rule-in tool but does not improve overall discriminatory ability.
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Authors | Edward W Carlton, Martin Than, Louise Cullen, Ahmed Khattab, Kim Greaves |
Journal | The American journal of medicine
(Am J Med)
Vol. 128
Issue 10
Pg. 1109-1116.e2
(Oct 2015)
ISSN: 1555-7162 [Electronic] United States |
PMID | 25912206
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved. |
Topics |
- Acute Coronary Syndrome
(complications, diagnosis)
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Area Under Curve
- Chest Pain
(diagnosis, etiology)
- Coronary Artery Disease
(complications, diagnosis)
- Diagnosis, Differential
- Emergency Service, Hospital
- Female
- Humans
- Learning Curve
- Male
- Middle Aged
- Myocardial Infarction
(complications, diagnosis)
- Prospective Studies
- Sensitivity and Specificity
- Young Adult
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