Macrophage activation: on par with LPS.

The inflammatory response is a critical component of the immune system that is activated by stimuli such as cytokines, foreign DNA, RNA, or other harmful substances. Krukenberg et al. (2015) identify poly(ADP-ribose) as a new signaling molecule that activates inflammation, thus providing yet another mechanism by which PARPs are involved in cellular stress responses.
AuthorsFlorian J Bock, Paul Chang
JournalChemistry & biology (Chem Biol) Vol. 22 Issue 4 Pg. 432-3 (Apr 23 2015) ISSN: 1879-1301 [Electronic] United States
PMID25910238 (Publication Type: Comment, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Ltd. All rights reserved.

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