Neurotrophins, cytokines, oxidative parameters and funcionality in Progressive Muscular Dystrophies.

Abstract

We investigated the levels of brain derived-neurotrophic factor (BDNF), cytokines and oxidative parameters in serum and tried to correlate them with the age and functionality of patients with Progressive Muscle Dystrophies (PMD). The patients were separated into six groups (case and controls pared by age and gender), as follows: Duchenne Muscular Dystrophy (DMD); Steinert Myotonic Dystrophy (SMD); and Limb-girdle Muscular Dystrophy type-2A (LGMD2A). DMD patients (± 17.9 years old) had a decrease of functionality, an increase in the IL-1β and TNF-α levels and a decrease of IL-10 levels and superoxide dismutase activity in serum. SMD patients (± 25.8 years old) had a decrease of BDNF and IL-10 levels and superoxide dismutase activity and an increase of IL-1β levels in serum. LGMD2A patients (± 27.7 years old) had an decrease only in serum levels of IL-10. This research showed the first evidence of BDNF involvement in the SMD patients and a possible unbalance between pro-inflammatory and anti-inflammatory cytokine levels, along with decreased superoxide dismutase activity in serum of DMD and SMD patients.

• Authors: Clarissa M Comim, Gisiane B Mathia, Andreza Hoepers, Lisiane Tuon, Flávio Kapczinski, Felipe Dal-Pizzol, João Quevedo, Maria I Rosa
• Journal: Anais da Academia Brasileira de Ciencias (An Acad Bras Cienc) Vol. 87 Issue 3 Pg. 1809-18 (Sep 2015) ISSN: 1678-2690 [Electronic] Brazil
• PMID: 25910175 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Cytokines
• Nerve Growth Factors

Topics

• Adolescent
• Adult
• Biomarkers (blood)
• Case-Control Studies
• Cytokines (blood)
• Disability Evaluation
• Disease Progression
• Female
• Humans
• Male
• Muscular Dystrophies, Limb-Girdle (blood)
• Muscular Dystrophy, Duchenne (blood)
• Myotonic Dystrophy (blood)
• Nerve Growth Factors (blood)
• Severity of Illness Index
• Young Adult