Abstract | OBJECTIVE: METHODS: Sixty SD rats were randomized into aluminum phosphate gel group (n=10), Kangfuxin group (n=10), aluminum phosphate gel+Kangfuxin group (n=10), model group (n=20), and control group (n=10). Except for those in the control group, all the rats were subjected to infusion of diluted lysolecithin with hydrochloric acid in the esophagus for 14 days. Ten rats in the model group and those in the control group were sacrificed to examine the pathological changes and contents of IL-8 and PGE2 in the esophagus using optical and electron microscopes and radioimmunoassay. The next day the rest rats were given corresponding treatments (saline in model group) administered into the esophagus on a daily basis for 14 days, after which esophageal pathologies and IL-8 and PGE2 contents were examined. RESULTS: The model rats showed obvious esophageal pathologies including inflammatory cell infiltration, vacuolar degeneration of the epithelial cells, esophageal erosion and even ulceration, with severe detachment of the epithelial cells. The rats in all the intervention groups showed lessened esophageal pathologies and lowered esophageal IL-8 and PGE2 contents compared with those in the model group. Esophageal mucosal injury index and IL-8 and PGE2 contents were all significantly lower in rats receiving combined treatment with aluminum phosphate and Kangfuxin than in those receiving either of the treatments (P<0.05). CONCLUSIONS:
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Authors | Hai-Ling Lin, Guo-Jian Li, Ji-Zhou Wu |
Journal | Nan fang yi ke da xue xue bao = Journal of Southern Medical University
(Nan Fang Yi Ke Da Xue Xue Bao)
Vol. 35
Issue 4
Pg. 573-7
(Apr 2015)
ISSN: 1673-4254 [Print] China |
PMID | 25907947
(Publication Type: Journal Article)
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Chemical References |
- Aluminum Compounds
- Drugs, Chinese Herbal
- Gels
- Interleukin-8
- Phosphates
- aluminum phosphate
- Dinoprostone
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Topics |
- Aluminum Compounds
(pharmacology)
- Animals
- Dinoprostone
(metabolism)
- Disease Models, Animal
- Drugs, Chinese Herbal
(pharmacology)
- Esophagitis, Peptic
(drug therapy, metabolism)
- Esophagus
(drug effects, pathology)
- Gels
- Interleukin-8
(metabolism)
- Phosphates
(pharmacology)
- Rats
- Rats, Sprague-Dawley
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