Abstract |
Axitinib is the most recent targeted therapy approved by the US FDA and EMA in the treatment of metastatic renal cell carcinoma (mRCC). It is a second-generation, orally available, potent tyrosine kinase inhibitor targeting selectively VEGF receptor (VEGFR)-1, -2 and -3, resulting in inhibition of angiogenesis, metastasis and tumor growth. Based on the results of a randomized pivotal Phase III clinical trial, axitinib stands as one of the two recommended agents for patients with mRCC who progressed after first-line tyrosine kinase inhibitor therapy. Its potent and selective inhibition of VEGFR was the rationale for its development in the second-line setting after failure of prior cytokines or sunitinib. Here we examine the preclinical and clinical data of axitinib for mRCC, and its use in the treatment algorithm.
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Authors | Laurence Albiges, Marco Gizzi, Edith Carton, Bernard Escudier |
Journal | Expert review of anticancer therapy
(Expert Rev Anticancer Ther)
Vol. 15
Issue 5
Pg. 499-507
(May 2015)
ISSN: 1744-8328 [Electronic] England |
PMID | 25907705
(Publication Type: Journal Article, Review)
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Chemical References |
- Imidazoles
- Indazoles
- Protein Kinase Inhibitors
- Axitinib
- Receptors, Vascular Endothelial Growth Factor
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Topics |
- Algorithms
- Axitinib
- Carcinoma, Renal Cell
(drug therapy, pathology)
- Disease Progression
- Humans
- Imidazoles
(pharmacology, therapeutic use)
- Indazoles
(pharmacology, therapeutic use)
- Kidney Neoplasms
(drug therapy, pathology)
- Molecular Targeted Therapy
- Neoplasm Metastasis
- Protein Kinase Inhibitors
(pharmacology, therapeutic use)
- Randomized Controlled Trials as Topic
- Receptors, Vascular Endothelial Growth Factor
(antagonists & inhibitors)
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