Abstract | BACKGROUND: METHODS:
Hyperuricemia was induced in mice by yeast extract paste or potassium oxonate. KD was given orally for 14 days at 200, 400 and 800 mg/kg/day, with Allopurinol 10 mg/kg/day as positive control. Serum uric acid (UA), and liver xanthine oxidase activity (XO) were measured. Scavenging activity of KD on 1, 1-diphenyl-2-picrylhydrazyl radicals (DPP•), nitric oxide (•NO), superoxide (O2•-), efficiency against lipid peroxidation, and XO inhibition were determined in vitro. RESULTS: KD inhibited liver XO activity and reduced serum uric acid in hyperuricemic mice. KD also showed noticeable antioxidant activity, scavenging free radicals (DPP•, •NO and O2•-). It was effective against lipid peroxidation and inhibited XO in vitro. CONCLUSIONS: This study supports the traditional use of Karapxa decoction to treat hyperuricemia and gout.
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Authors | Nurmuhammat Amat, Anwar Umar, Parida Hoxur, Mihrigul Anaydulla, Guzalnur Imam, Ranagul Aziz, Halmurat Upur, Anake Kijjoa, Nicholas Moore |
Journal | BMC complementary and alternative medicine
(BMC Complement Altern Med)
Vol. 15
Pg. 131
(Apr 25 2015)
ISSN: 1472-6882 [Electronic] England |
PMID | 25906842
(Publication Type: Journal Article)
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Chemical References |
- Free Radicals
- Plant Extracts
- Uric Acid
- Xanthine Oxidase
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Topics |
- Animals
- Apiaceae
- Asteraceae
- Convolvulaceae
- Free Radicals
(metabolism)
- Hyperuricemia
(drug therapy, metabolism)
- Liver
(drug effects, metabolism)
- Medicine, Traditional
- Mice
- Phytotherapy
- Plant Extracts
(pharmacology, therapeutic use)
- Uric Acid
(blood)
- Xanthine Oxidase
(antagonists & inhibitors)
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