Abstract | BACKGROUND/AIM: We aimed to compared estimated glomerular filtration rate (eGFR) according to the Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI), with (mL/min/1.73 m(2) ) and without body surface area (BSA) normalisation (CKD-EPI_noBSA, mL/min) against measured ( 99m) Technetium - diethylenepentaacetic acid ( Tc-DTPA GFR) (mL/min) in 222 individuals, including 80 with malignancy. METHODS: BSA was calculated for each individual using the Du Bois equation. The CKD-EPI and CKD-EPI_noBSA equations were compared with measured Tc-DTPA GFR with respect to bias, proportion within 30% of GFR (P30) and root mean square error for predicting levels of GFR, and concordance in relation to carboplatin dosing. RESULTS: The mean (SD) for BSA and measured GFR for the entire group was 1.99 (0.25) m(2) and 127 (41) mL/min respectively. The P30 for Tc-DTPA GFR was significantly higher with the CKD-EPI_noBSA (80%) than with the CKD-EPI equation (63%, P = 0.0001). In those with body mass index (BMI) > 30 kg/m(2) , the P30 values for the CKD-EPI_noBSA and CKD-EPI were 74% and 42% respectively (P < 0.0001). Carboplatin dosing concordance for the cancer patients using the CKD-EPI and CKD-EPI_noBSA equation was 71% and 56% respectively (P = 0.07). In 78 individuals with BMI > 30 kg/m(2) , concordance in relation to carboplatin dosing using CKD-EPI_noBSA was 65% compared with 26% with the CKD-EPI (P < 0.0001). CONCLUSION: The CKD-EPI without normalisation (CKD-EPI_noBSA) equation was superior to the CKD-EPI equation in estimating raw-measured Tc-DTPA GFR (mL/min).
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Authors | J S C Chew-Harris, P K L Chin, C M Florkowski, P George, Z Endre |
Journal | Internal medicine journal
(Intern Med J)
Vol. 45
Issue 7
Pg. 766-73
(Jul 2015)
ISSN: 1445-5994 [Electronic] Australia |
PMID | 25904102
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 Royal Australasian College of Physicians. |
Chemical References |
- Carboplatin
- Technetium Tc 99m Pentetate
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Topics |
- Adult
- Aged
- Body Mass Index
- Body Surface Area
- Carboplatin
(pharmacokinetics)
- Glomerular Filtration Rate
(physiology)
- Humans
- Middle Aged
- Obesity
(metabolism)
- Renal Insufficiency, Chronic
(metabolism)
- Technetium Tc 99m Pentetate
(metabolism)
- Young Adult
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