Pyridinic analog of the natural product (-)-spectaline as potential adjuvant for the treatment of central nervous system disorders.

Abstract

Previously we designed a series of pyridinic anticholinesterasic compounds based on molecular hybridization between tacrine and the natural piperidine alkaloid (-)-3-O-acetylspectaline isolated from Senna spectabilis. Based on the information that the cholinergic system has an important role in the treatment of schizophrenia and depression, we herein report the evaluation of a series of pyridinic compounds in animal models for antipsychotic and antidepressant-like activities. Compound 2 decreased the immobility time of mice in the forced swimming test (5 and 10mg/kg p.o.) and prevented the climbing behavior induced by apomorphine (10mg/kg, p.o.), without impairing animals locomotor activity.

• Authors: Marilia Valli, Andresa Heemann Betti, Amanda Danuello, Marcos Pivatto, Fernanda Centurião, Camila Boque Antonio, Stela Maris Kuze Rates, Vanderlan da Silva Bolzani
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 25 Issue 10 Pg. 2247-50 ( 2015) ISSN: 1464-3405 [Electronic] England
• PMID: 25900218 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Antidepressive Agents
• Piperidines
• Pyridines
• spectaline

Topics

• Animals
• Antidepressive Agents (chemical synthesis, chemistry, pharmacology)
• Behavior, Animal (drug effects)
• Central Nervous System Diseases (drug therapy)
• Disease Models, Animal
• Mice
• Piperidines (chemical synthesis, chemistry, pharmacology, therapeutic use)
• Pyridines (chemical synthesis, chemistry, pharmacology)
• Schizophrenia (drug therapy)