Immunoglobulin G4-related orbital disease: report of two pediatric cases.

Abstract

IgG4-related disease is a systemic fibro-inflammatory disorder mainly affecting the middle-aged and elderly population. IgG4-related orbital disease is very rare in childhood. We present here two children with IgG4-related orbital disease, one of whom responded well to prednisolone treatment while the other one was refractory to most immunosuppressive agents. It is important to treat patients at the early active stage of disease before fibrotic changes predominate. Thus, although rare, increased awareness of IgG4-related orbital disease in childhood may avoid delays in diagnosis and treatment.

• Authors: Ezgi Deniz Batu, Zehra Serap Arici, Diclehan Orhan, Hayyam Kiratli, Seza Özen
• Journal: Clinical and experimental rheumatology (Clin Exp Rheumatol) 2015 May-Jun Vol. 33 Issue 3 Pg. 409-410 ISSN: 0392-856X [Print] Italy
• PMID: 25897575 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers
• Glucocorticoids
• Immunoglobulin G
• Immunosuppressive Agents
• Prednisolone

Topics

• Adolescent
• Autoimmune Diseases (diagnosis, drug therapy, immunology)
• Biomarkers (analysis)
• Biopsy
• Child
• Early Diagnosis
• Female
• Glucocorticoids (therapeutic use)
• Humans
• Immunoglobulin G (analysis)
• Immunohistochemistry
• Immunosuppressive Agents (therapeutic use)
• Orbital Diseases (diagnosis, drug therapy, immunology)
• Predictive Value of Tests
• Prednisolone (therapeutic use)
• Treatment Outcome