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Spectrum of histopathologic diagnosis of lymph node biopsies after liver and kidney transplant.

AbstractOBJECTIVES:
Our aim was to review our single center experience regarding histopathologic features arising from enlarged lymph nodes following solidorgan transplant.
MATERIALS AND METHODS:
In 2148 people who had solid-organ transplant from 1985 to 2013, there were 34 patients (1.58%) who developed lymphadenopathy. A retrospective review was performed to evaluate demographic, clinical, and histopathologic features of medical and pathologic records.
RESULTS:
Nonneoplastic lesions were more common, comprising 70.5% (n = 24) all cases which included nonspecific reactive lymphoid hyperplasia in 8 patients (33.3%), tuberculous lymphadenitis in 6 patients (25%), amyloid lymphadenopathy in 4 patients (16.6%), dermatopathic lymphadenopathy in 2 patients (8.3%), Kikuchi-Fujimoto disease in 1 patient (4.16%), hemangioma in 1 patient (4.16%), plasmacytic form of Castleman disease and amyloid lymphadenopathy in 1 patient (4.16%), and sea blue histiocytosis in 1 patient (4.16%). Neoplastic lesions comprised 29.41% (n = 10) cases which included posttransplant lymphoproliferative disorder in 6 patients (60%), Kaposi sarcoma in 2 patients (20%), posttransplant lymphoproliferative disorder and Kaposi sarcoma in 1 patient (10%), and metastatic carcinoma in 1 patient (10%).
CONCLUSIONS:
Detecting enlarged lymph nodes in solid-organ transplant recipients is an infrequent occurrence. Infectious diseases, posttransplant lymphoproliferative disorder, and malignancies related to transplant should be considered in the differential diagnosis when enlarged lymph nodes in solid-organ transplant recipients are encountered.
AuthorsEylem Akar Özkan, B Handan Özdemir, E Şebnem Ayva, Funda Gerçeker, Fatih Boyvat, Mehmet Haberal
JournalExperimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation (Exp Clin Transplant) Vol. 13 Suppl 1 Pg. 177-82 (Apr 2015) ISSN: 2146-8427 [Electronic] Turkey
PMID25894150 (Publication Type: Journal Article)
Topics
  • Adolescent
  • Adult
  • Biopsy
  • Child
  • Child, Preschool
  • Diagnosis, Differential
  • Female
  • Humans
  • Infant
  • Kidney Transplantation (adverse effects)
  • Liver Transplantation (adverse effects)
  • Lymph Nodes (pathology)
  • Lymphoproliferative Disorders (etiology, pathology)
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Retrospective Studies
  • Risk Factors
  • Time Factors
  • Treatment Outcome
  • Young Adult

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