Abstract | OBJECTIVES: Our aim was to review our single center experience regarding histopathologic features arising from enlarged lymph nodes following solidorgan transplant. MATERIALS AND METHODS: In 2148 people who had solid-organ transplant from 1985 to 2013, there were 34 patients (1.58%) who developed lymphadenopathy. A retrospective review was performed to evaluate demographic, clinical, and histopathologic features of medical and pathologic records. RESULTS: Nonneoplastic lesions were more common, comprising 70.5% (n = 24) all cases which included nonspecific reactive lymphoid hyperplasia in 8 patients (33.3%), tuberculous lymphadenitis in 6 patients (25%), amyloid lymphadenopathy in 4 patients (16.6%), dermatopathic lymphadenopathy in 2 patients (8.3%), Kikuchi-Fujimoto disease in 1 patient (4.16%), hemangioma in 1 patient (4.16%), plasmacytic form of Castleman disease and amyloid lymphadenopathy in 1 patient (4.16%), and sea blue histiocytosis in 1 patient (4.16%). Neoplastic lesions comprised 29.41% (n = 10) cases which included posttransplant lymphoproliferative disorder in 6 patients (60%), Kaposi sarcoma in 2 patients (20%), posttransplant lymphoproliferative disorder and Kaposi sarcoma in 1 patient (10%), and metastatic carcinoma in 1 patient (10%). CONCLUSIONS: Detecting enlarged lymph nodes in solid-organ transplant recipients is an infrequent occurrence. Infectious diseases, posttransplant lymphoproliferative disorder, and malignancies related to transplant should be considered in the differential diagnosis when enlarged lymph nodes in solid-organ transplant recipients are encountered.
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Authors | Eylem Akar Özkan, B Handan Özdemir, E Şebnem Ayva, Funda Gerçeker, Fatih Boyvat, Mehmet Haberal |
Journal | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
(Exp Clin Transplant)
Vol. 13 Suppl 1
Pg. 177-82
(Apr 2015)
ISSN: 2146-8427 [Electronic] Turkey |
PMID | 25894150
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Biopsy
- Child
- Child, Preschool
- Diagnosis, Differential
- Female
- Humans
- Infant
- Kidney Transplantation
(adverse effects)
- Liver Transplantation
(adverse effects)
- Lymph Nodes
(pathology)
- Lymphoproliferative Disorders
(etiology, pathology)
- Male
- Middle Aged
- Predictive Value of Tests
- Retrospective Studies
- Risk Factors
- Time Factors
- Treatment Outcome
- Young Adult
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