Abstract |
Blood transfusions can induce alloantibodies to antigens on red blood cells (RBCs), white blood cells and platelets, with these alloantibodies affecting transfusion and transplantation. While transfusion-related alloimmunization against RBC antigens and human leucocyte antigens (HLA) have been studied, transfusion-related alloimmunization to minor histocompatibility antigens (mHA), such as H-Y antigens, has not been clinically characterized. We conducted a cross-sectional study of 114 children with sickle cell disease (SCD) and tested for antibodies to 5 H-Y antigens and to HLA class I and class II. Few patients had H-Y antibodies, with no significant differences in the prevalence of any H-Y antibody observed among transfused females (7%), transfused males (6%) and never transfused females (4%). In contrast, HLA class I, but not HLA class II, antibodies were more prevalent among transfused than never transfused patients (class I: 33% vs. 13%, P = 0·046; class II: 7% vs. 8%, P = 0·67). Among transfused patients, RBC alloantibody history but not amount of transfusion exposure was associated with a high (>25%) HLA class I panel reactive antibody (Odds ratio 6·8, 95% confidence interval 2·1-22·3). These results are consistent with immunological responder and non-responder phenotypes, wherein a subset of patients with SCD may be at higher risk for transfusion-related alloimmunization.
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Authors | Robert S Nickel, Jeanne E Hendrickson, Marianne M Yee, Robert A Bray, Howard M Gebel, Leslie S Kean, David B Miklos, John T Horan |
Journal | British journal of haematology
(Br J Haematol)
Vol. 170
Issue 2
Pg. 247-56
(Jul 2015)
ISSN: 1365-2141 [Electronic] England |
PMID | 25891976
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 John Wiley & Sons Ltd. |
Chemical References |
- H-Y Antigen
- Histocompatibility Antigens Class I
- Isoantibodies
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Topics |
- Adolescent
- Anemia, Sickle Cell
(immunology, therapy)
- Child
- Child, Preschool
- Cross-Sectional Studies
- Erythrocyte Transfusion
(adverse effects)
- Female
- H-Y Antigen
(immunology)
- Histocompatibility Antigens Class I
(immunology)
- Humans
- Immunophenotyping
- Isoantibodies
(blood, immunology)
- Male
- Odds Ratio
- Young Adult
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