Abstract | BACKGROUND: Several investigations have been performed to examine the influence of the β- fibrinogen (FGβ) gene polymorphisms on the risk of ischemic stroke, but the results of these studies are controversial. Our study aimed at investigating whether the FGβ gene (-148 C/T, 448 G/A, and -854 G/A) polymorphisms were associated with susceptibility to ischemic stroke by conducting meta-analysis. METHODS: Relevant studies were identified from 4 Chinese databases, PUBMED and EMBASE before May 30, 2014. The strength of association was evaluated by the odds ratio with 95% confidence interval. Inconsistency index and the Cochran's Q statistic were used to check heterogeneity. Publication bias was tested using funnel plots and Egger's regression test. RESULTS: Thirty-two independent studies with 4311 cases and 4124 controls were included. Significant association between -148 C/T polymorphism and the risk of ischemic stroke was found in overall analysis and middle-age, but not in young adults and elderly people. Similarly, association was also observed for -854 G/A polymorphism, especially in cerebral arterial main trunk infarction (MCI) and cerebral penetrating arterial infarction (PCI). However, no significance was found between 448 G/A polymorphism and ischemic stroke in Chinese people; likewise, no evidence of a significant association was observed when stratified according to the subtype of ischemic stroke (MCI and PCI). CONCLUSIONS: These results suggest that -148 C/T and -854 G/A polymorphisms probably contribute to susceptibility of ischemic stroke.
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Authors | Guangliang Wu, Haiyan Cai, Haobin Cai, Zhao Chen, Lei Tan, Huitao Qi, Yefeng Cai |
Journal | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
(J Stroke Cerebrovasc Dis)
Vol. 24
Issue 7
Pg. 1577-90
(Jul 2015)
ISSN: 1532-8511 [Electronic] United States |
PMID | 25890854
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- FGB protein, human
- Fibrinogen
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Topics |
- Asian People
(genetics)
- Brain Ischemia
(diagnosis, ethnology, genetics)
- Case-Control Studies
- China
(epidemiology)
- Fibrinogen
(genetics)
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Odds Ratio
- Phenotype
- Polymorphism, Genetic
- Risk Factors
- Stroke
(diagnosis, ethnology, genetics)
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