Abstract | BACKGROUNDS: On the basis of Custodiol preservation and cardioplegic solution a novel cardioplegic solution was developed to improve the postischemic cardiac and endothelial function. In this study, we investigated whether its reduced cytotoxicity and its ability to reduce reactive oxygen species generation during hypoxic condition have beneficial effects in a clinically relevant canine model of CPB. METHODS: RESULTS: The use of Custodiol-N cardioplegic solution improved coronary blood flow (58 ± 7 ml/min vs. 26 ± 3 ml/min) and effectively prevented cardiac dysfunction after cardiac arrest. In addition, the myocardial ATP content (12,8 ± 1,0 μmol/g dry weight vs. 9,5 ± 1,5 μmol/g dry weight) and plasma nitrite (1,1 ± 0,3 ng/ml vs. 0,5 ± 0,2 ng/ml) were significantly higher after application of the new cardioplegic solution. Furthermore, plasma myeloperoxidase level (3,4 ± 0,4 ng/ml vs. 4,3 ± 2,2 ng/ml) significantly decreased in Custodiol-N group. CONCLUSIONS:
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Authors | Gábor Veres, Tamás Radovits, Béla Merkely, Matthias Karck, Gábor Szabó |
Journal | Journal of cardiothoracic surgery
(J Cardiothorac Surg)
Vol. 10
Pg. 27
(Feb 28 2015)
ISSN: 1749-8090 [Electronic] England |
PMID | 25890005
(Publication Type: Journal Article)
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Chemical References |
- Cardioplegic Solutions
- Custodiol-N solution
- Organ Preservation Solutions
- Reactive Oxygen Species
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Topics |
- Animals
- Cardioplegic Solutions
(pharmacology, therapeutic use)
- Cardiopulmonary Bypass
(adverse effects)
- Coronary Circulation
(drug effects, physiology)
- Dogs
- Drug Evaluation, Preclinical
(methods)
- Endothelium, Vascular
(physiopathology)
- Heart Arrest, Induced
(methods)
- Hemodynamics
(drug effects, physiology)
- Myocardial Reperfusion Injury
(etiology, prevention & control)
- Organ Preservation Solutions
(pharmacology, therapeutic use)
- Reactive Oxygen Species
(blood)
- Ventricular Function, Left
(drug effects, physiology)
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