Abstract | INTRODUCTION: Although there is an increase in clinical trials assessing the efficacy of cell therapy in structural and functional regeneration after stroke, there are not enough data in the literature describing the best cell type to be used, the best route, and also the best nanoparticle to analyze these stem cells in vivo. This review analyzed published data on superparamagnetic iron oxide nanoparticle (SPION)-labeled stem cells used for ischemic stroke therapy. METHOD: We performed a systematic review and meta-analysis of data from experiments testing the efficacy of cellular treatment with SPION versus no treatment to improve behavioral or modified neural scale outcomes in animal models of stroke by the Cochrane Collaboration and indexed in EMBASE, PubMed, and Web of Science since 2000. To test the impact of study quality and design characteristics, we used random-effects meta-regression. In addition, trim and fill were used to assess publication bias. RESULTS: The search retrieved 258 articles. After application of the inclusion criteria, 24 reports published between January 2000 and October 2014 were selected. These 24 articles were analyzed for nanoparticle characteristics, stem cell types, and efficacy in animal models. CONCLUSION: This study highlights the therapeutic role of stem cells in stroke and emphasizes nanotechnology as an important tool for monitoring stem cell migration to the affected neurological locus.
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Authors | Leopoldo P Nucci, Helio R Silva, Viviana Giampaoli, Javier B Mamani, Mariana P Nucci, Lionel F Gamarra |
Journal | Stem cell research & therapy
(Stem Cell Res Ther)
Vol. 6
Pg. 27
(Mar 13 2015)
ISSN: 1757-6512 [Electronic] England |
PMID | 25889904
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
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Chemical References |
- Ferric Compounds
- Magnetite Nanoparticles
- ferric oxide
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Topics |
- Animals
- Brain Ischemia
(therapy)
- Cell- and Tissue-Based Therapy
(methods)
- Disease Models, Animal
- Ferric Compounds
(therapeutic use)
- Humans
- Magnetite Nanoparticles
(therapeutic use)
- Metal Nanoparticles
(therapeutic use)
- Staining and Labeling
- Stem Cell Transplantation
- Stem Cells
(physiology)
- Stroke
(therapy)
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