Abstract | BACKGROUND: METHODS: Rat model of chronic cerebral injury was established by chronic intragastric administration of aluminum gluconate(Al3+ 200 mg/kg per day,5d a week for 20 weeks). The methods of ELISA, qRT-PCR and Western blotting were used to detect the PGI2 level and the PGIS and IP mRNA and protein levels in hippocampi of chronic aluminum-overload rats, respectively. Rat hippocampal superoxide dismutase (SOD) activity and malondialdehyde (MDA) content also were measured. The effects of BPS (6, 12 and 24 μg⋅kg(-1)) on brain injury in chronic aluminum-overload rats were evaluated. RESULTS: Compared with the control group, PGIS mRNA expression, PGI2 level, and the IP mRNA and protein expressions significantly increased in hippocampi of chronic aluminum-overload rats. Administration of BPS significantly improved spatial learning and memory function impairment and hippocampal neuron injury induced by chronic aluminum overload in rats. Meanwhile, administration of BPS resulted in a decrease of PGI2 level and downregulation of PGIS and IP expressions in a dose-dependent manner. Aluminum overload also caused a decrease of SOD activity and an increase of MDA content. Administration of BPS significantly blunted the decrease of SOD activity and the increase of MDA content induced by aluminum overload in rats. CONCLUSIONS:
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Authors | Yongquan Pan, Lijuan Yu, Wenjuan Lei, Yuanxin Guo, Jianfeng Wang, Huarong Yu, Yong Tang, Junqing Yang |
Journal | Behavioral and brain functions : BBF
(Behav Brain Funct)
Vol. 11
Pg. 6
(Feb 07 2015)
ISSN: 1744-9081 [Electronic] England |
PMID | 25888780
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aluminum Compounds
- Anti-Inflammatory Agents, Non-Steroidal
- Gluconates
- Nerve Tissue Proteins
- Neuroprotective Agents
- Receptors, Epoprostenol
- beraprost
- Malondialdehyde
- Cytochrome P-450 Enzyme System
- Aluminum
- Epoprostenol
- Superoxide Dismutase
- Intramolecular Oxidoreductases
- prostacyclin synthetase
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Topics |
- Aluminum
(metabolism)
- Aluminum Compounds
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Brain Damage, Chronic
(chemically induced, prevention & control)
- Cytochrome P-450 Enzyme System
(metabolism)
- Epoprostenol
(analogs & derivatives, biosynthesis, therapeutic use)
- Gluconates
- Hippocampus
(metabolism, pathology)
- Intramolecular Oxidoreductases
(metabolism)
- Male
- Malondialdehyde
(metabolism)
- Maze Learning
(drug effects)
- Memory Disorders
(chemically induced, prevention & control, psychology)
- Nerve Tissue Proteins
(biosynthesis)
- Neuroprotective Agents
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Receptors, Epoprostenol
(drug effects)
- Superoxide Dismutase
(metabolism)
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