Abstract | BACKGROUND:
Aloperine, a natural alkaloid constituent isolated from the herb Sophora alopecuroides displays anti-inflammatory properties in vitro and in vivo. Our group previously demonstrated that aloperine significantly induced apoptosis in colon cancer SW480 and HCT116 cells. However, its specific target(s) remain to be discovered in multiple myeloma (MM) and have not been investigated. METHODS: Human myeloma cell lines (n = 8), primary myeloma cells (n = 12), drug-resistant myeloma cell lines (n = 2), and animal models were tested for their sensitivity to aloperine in terms of proliferation and apoptosis both in vitro and in vivo, respectively. We also examined the functional mechanisms underlying the apoptotic pathways triggered by aloperine. RESULTS: CONCLUSIONS:
Aloperine has multifaceted antitumor effects on MM cells. Our data support the clinical development of aloperine for MM therapy.
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Authors | He Wang, Shu Yang, Hong Zhou, Mingna Sun, Lingran Du, Minyan Wei, Meixia Luo, Jingzhu Huang, Hongzhu Deng, Yinghong Feng, Jun Huang, Yi Zhou |
Journal | Journal of hematology & oncology
(J Hematol Oncol)
Vol. 8
Pg. 26
(Mar 15 2015)
ISSN: 1756-8722 [Electronic] England |
PMID | 25886453
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Piperidines
- Quinolizidines
- RNA, Small Interfering
- aloperine
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Apoptosis
(drug effects)
- Blotting, Western
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Cells, Cultured
- Humans
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Multiple Myeloma
(pathology)
- Piperidines
(pharmacology)
- Quinolizidines
- RNA, Small Interfering
- Transfection
- Xenograft Model Antitumor Assays
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