Abstract | CONTEXT: OBJECTIVE: The purpose of this study was to investigate whether a history of hypertension and the use of specific antihypertensive medications determine the risk for developing P-HPTH in a large prospective study. DESIGN/PARTICIPANTS: A longitudinal prospective cohort of female nurses in the Nurses' Health Study I (n = 75 600), who did not have P-HPTH at baseline and completed a questionnaire assessment of lifetime history of P-HPTH were followed from 1986 to 2008. Most participants were white and postmenopausal. SETTING: The study was a nationwide cohort study. MAIN OUTCOME MEASURE: Incident P-HPTH was assessed initially via questionnaire and then was confirmed by medical record review. Cox proportional hazards models were used to adjust for potential confounders. RESULTS: We documented 347 incident cases of P-HPTH during 1 719 416 person-years of follow-up. The age-adjusted relative risk (RR) for incident P-HPTH associated with hypertension was 1.80 (95% confidence interval [CI], 1.43-2.26), and the multivariate-adjusted RR was 1.45 (95% CI, 1.10-1.91). Among participants with a history of hypertension, the use of furosemide, when compared with the use of other antihypertensive medications, was associated with increased risk for developing P-HPTH; age-adjusted RR for incident P-HPTH was 1.79 (95% CI, 1.15-2.79) and multivariate-adjusted RR was 1.71 (95% CI, 1.08-2.71). CONCLUSIONS: In a large longitudinal prospective cohort study of mostly older white women, a history of hypertension and use of furosemide were associated with a significantly higher risk of developing P-HPTH.
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Authors | Anand Vaidya, Gary C Curhan, Julie M Paik, Henry Kronenberg, Eric N Taylor |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 100
Issue 6
Pg. 2396-404
(Jun 2015)
ISSN: 1945-7197 [Electronic] United States |
PMID | 25885946
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Furosemide
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Topics |
- Adult
- Antihypertensive Agents
(therapeutic use)
- Female
- Furosemide
(therapeutic use)
- Humans
- Hyperparathyroidism, Primary
(epidemiology, etiology)
- Hypertension
(complications, drug therapy, epidemiology)
- Incidence
- Longitudinal Studies
- Middle Aged
- Nurses
(statistics & numerical data)
- Risk Factors
- United States
(epidemiology)
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