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Angiomyomatous hamartoma in an inguinal lymph node with proliferating pericytes/smooth muscle cells, plexiform vessel tangles, and ectopic calcification.

Abstract
Angiomyomatous hamartoma (AMH) is a rare benign lesion, which occurs almost exclusively in the inguinal lymph nodes. We herein report a case of a female elder who presented with a long-standing inguinal mass. Microscopically, the mass showed a zonal distribution, characterized by thick-walled muscular vessels, fibrosis, and calcification in the hilum and proliferating spindle cells around thin-walled vessels and plexiform vessel tangles at the periphery. The spindle cells show positive immunoreactivity of smooth muscle actin and CD34 with a heterogeneous expression of desmin and CD44. Although the pathogenesis of AMH remains uncertain, the histological features and immunohistochemical findings of this case imply a disordered or exuberant angiogenic process.
AuthorsChii-Hong Lee, Tung-Cheng Chang, Jan-Wen Ku
JournalIndian journal of pathology & microbiology (Indian J Pathol Microbiol) 2015 Apr-Jun Vol. 58 Issue 2 Pg. 226-8 ISSN: 0974-5130 [Electronic] India
PMID25885141 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antigens, CD34
  • Biomarkers, Tumor
  • CD44 protein, human
  • Desmin
  • Hyaluronan Receptors
Topics
  • Aged, 80 and over
  • Antigens, CD34 (analysis)
  • Biomarkers, Tumor (analysis)
  • Calcinosis
  • Desmin (analysis)
  • Female
  • Fibrosis
  • Hamartoma (diagnosis, pathology)
  • Histocytochemistry
  • Humans
  • Hyaluronan Receptors (analysis)
  • Immunohistochemistry
  • Lymph Nodes (pathology)
  • Microscopy
  • Muscle Cells (pathology)
  • Pericytes (pathology)

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