Effect of delayed graft function, acute rejection and chronic allograft dysfunction on kidney allograft telomere length in patients after transplantation: a prospective cohort study.

Abstract

BACKGROUND:

The outcome of kidney allograft transplantation is associated with numerous donor-dependent and recipient-dependent immunological and non-immunological factors. Studies on genetic factors affecting the non-immunological aspects, like ageing of the kidney allograft and patient outcome are still lacking. The aim of this study was the analysis of relative telomere length (RTL; T/S ratio) in the biopsy specimens of the transplanted kidney allograft and its correlation with the delayed graft function (DGF), acute rejection (AR) and chronic allograft dysfunction (CAD).

METHODS:

The study enrolled 119 Caucasian kidney allograft recipients (64 M/55 F, mean age 47.32 ± 14.03; transplantation performed between 2001 and 2012). Organs were harvested from cadaveric donors (59.8 M/40.2 F, mean age 45.99 ± 14.62).

RESULTS:

There were significant differences in RTL assessed in kidney allograft biopsy specimens collected 3-6 months after transplantation between patients with DGF and without DGF (181.8 ± 82.0 vs. 284.6 ± 149.6; p < 0.05) and in RTL of kidney allograft biopsy specimens collected 18-60 months after transplantation between patients with AR and without AR (188.1 ± 162.1 vs. 263.3 ± 134.7; p = 0.047). There were significant differences in RTL assessed in kidney allograft biopsy specimens collected 12-24 months after transplantation between patients with CAD and without CAD (168.0 ± 120.0 vs. 282.1 ± 158.4; p = 0.038).

CONCLUSIONS:

Duration of dialysis before transplantation and PRA influence the kidney allograft ageing. Telomere length assessed in biopsy specimens collected in the peri-transplant period predicts the long-term kidney allograft function. Complications of kidney transplantation, like DGF, AR and CAD are linked with the telomere length and thus, graft ageing.

• Authors: Leszek Domański, Karolina Kłoda, Ewa Kwiatkowska, Ewa Borowiecka, Krzysztof Safranow, Arleta Drozd, Andrzej Ciechanowicz, Kazimierz Ciechanowski
• Journal: BMC nephrology (BMC Nephrol) Vol. 16 Pg. 23 (Feb 18 2015) ISSN: 1471-2369 [Electronic] England
• PMID: 25884882 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Acute Disease
• Adult
• Allografts (metabolism, pathology)
• Cadaver
• Cellular Senescence (genetics)
• Chronic Disease
• Cohort Studies
• Delayed Graft Function (genetics, metabolism, pathology)
• Female
• Graft Rejection (genetics, metabolism, pathology)
• Humans
• Kidney (metabolism, pathology)
• Kidney Failure, Chronic (therapy)
• Kidney Transplantation
• Male
• Middle Aged
• Primary Graft Dysfunction (genetics, metabolism, pathology)
• Prospective Studies
• Renal Dialysis
• Telomere (metabolism)
• Telomere Shortening (genetics)
• Time Factors