Sensitivity of the modified Children's Yale-Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials.

Abstract

Repetitive behavior is a core feature of autism spectrum disorder. We used 8-week data from two federally funded, multi-site, randomized trials with risperidone conducted by the Research Units on Pediatric Psychopharmacology Autism Network to evaluate the sensitivity of the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder to detect change with treatment. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. In Study 2, 49 subjects received risperidone only and 75 subjects received risperidone plus parent training. The combined sample consisted of 187 boys and 38 girls (aged 4-17 years). At the medication-free baseline, the internal consistency on the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder total score was excellent (Cronbach's alpha = 0.84) and the mean scores were similar across the four groups. Compared to placebo in Study 1, all three active treatment groups showed significant improvement (effect sizes: 0.74-0.88). There were no differences between active treatment groups. These results indicate that the Children's Yale-Brown Obsessive Compulsive Scale modified for autism spectrum disorder has acceptable test-retest as evidenced by the medium to high correlations in the placebo group and demonstrated sensitivity to change with treatment.

• Authors: Lawrence Scahill, Denis G Sukhodolsky, Emily Anderberg, Anastasia Dimitropoulos, James Dziura, Michael G Aman, James McCracken, Elaine Tierney, Victoria Hallett, Karol Katz, Benedetto Vitiello, Christopher McDougle
• Journal: Autism : the international journal of research and practice (Autism) Vol. 20 Issue 2 Pg. 145-52 (Feb 2016) ISSN: 1461-7005 [Electronic] England
• PMID: 25882391 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
• Copyright: © The Author(s) 2015.

Chemical References

• Antipsychotic Agents
• Risperidone

Topics

• Adolescent
• Antipsychotic Agents (therapeutic use)
• Autism Spectrum Disorder (complications)
• Child
• Child, Preschool
• Double-Blind Method
• Female
• Health Education
• Humans
• Male
• Obsessive-Compulsive Disorder (complications, diagnosis, therapy)
• Parents
• Psychiatric Status Rating Scales (standards)
• Risperidone (therapeutic use)