Anti-C1q antibodies as a follow-up marker in SLE patients.

Abstract

In cross-sectional studies autoantibodies against complement C1q (anti-C1q) were found to be highly associated with active lupus nephritis. The aim of this retrospective study was to determine the value of anti-C1q as follow-up marker of disease activity and renal involvement in patients with systemic lupus erythematosus (SLE). Fifty-two patients with SLE and a minimum of three anti-C1q measurements during follow-up were analyzed. Anti-C1q levels correlated with global disease activity scores. In subgroup analyses, patients without renal involvement did not show a significant correlation between anti-C1q levels and disease activity. In contrast, in patients with renal involvement, anti-C1q levels correlated well with global disease activity. In addition, a positive correlation with the urine protein-to-creatinine ratio and anti-dsDNA antibody levels as well as a negative correlation with complement levels was observed. Anti-C1q antibodies were found to strongly correlate with parameters of SLE disease activity during follow-up, in particular with regard to renal involvement.

• Authors: Merete Bock, Ingmar Heijnen, Marten Trendelenburg
• Journal: PloS one (PLoS One) Vol. 10 Issue 4 Pg. e0123572 ( 2015) ISSN: 1932-6203 [Electronic] United States
• PMID: 25881125 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Biomarkers
• Complement C1q

Topics

• Adolescent
• Adult
• Aged
• Autoantibodies (blood, immunology)
• Biomarkers (blood)
• Complement C1q (immunology)
• Female
• Follow-Up Studies
• Humans
• Lupus Erythematosus, Systemic (blood, immunology, physiopathology)
• Male
• Middle Aged
• Retrospective Studies
• Young Adult