Abstract | BACKGROUND: METHODS: Pseudoviruses derived from nine treatment-experienced patients infected with HIV-1 were investigated by comparison with the wild-type strain pNL4-3. The 50% inhibitory concentration (IC50) values were calculated and drug susceptibility was compared. The intensity of genotypic drug resistance was classified based on the 'SIR' interpretation of the Stanford data base. RESULTS: CONCLUSIONS:
Etravirine and darunavir have been used in HAART since 2010 in South Korea. Therefore, these antiretroviral drugs together with other newly introduced antiretroviral drugs are interesting for the optimal treatment of patients with treatment failure. This study may help to find a more effective HAART in the case of HIV-1 infected patients that have difficulty being treated.
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Authors | Oh-Kyung Kwon, Sung Soon Kim, Jee Eun Rhee, Mee-Kyung Kee, Mina Park, Hye-Ri Oh, Ju-Yeon Choi |
Journal | Virology journal
(Virol J)
Vol. 12
Pg. 53
(Apr 09 2015)
ISSN: 1743-422X [Electronic] England |
PMID | 25879840
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-HIV Agents
- Nitriles
- Protein Precursors
- Pyridazines
- Pyrimidines
- gag Gene Products, Human Immunodeficiency Virus
- pol Gene Products, Human Immunodeficiency Virus
- pr160 gag-pol precursor protein, Human immunodeficiency virus 1
- etravirine
- Darunavir
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Topics |
- Acquired Immunodeficiency Syndrome
(drug therapy, virology)
- Anti-HIV Agents
(pharmacology, therapeutic use)
- Antiretroviral Therapy, Highly Active
- Darunavir
(pharmacology, therapeutic use)
- Drug Resistance, Viral
- Genotype
- HIV Infections
(drug therapy, virology)
- HIV-1
(genetics)
- Humans
- Inhibitory Concentration 50
- Microbial Sensitivity Tests
- Mutation
- Nitriles
- Phenotype
- Protein Precursors
(genetics)
- Pyridazines
(pharmacology, therapeutic use)
- Pyrimidines
- Recombination, Genetic
- Republic of Korea
- gag Gene Products, Human Immunodeficiency Virus
(genetics)
- pol Gene Products, Human Immunodeficiency Virus
(genetics)
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