Cystine growth inhibition through molecular mimicry: a new paradigm for the prevention of crystal diseases.

Abstract

Cystinuria is a genetic disease marked by recurrent kidney stone formation, usually at a young age. It frequently leads to chronic kidney disease. Treatment options for cystinuria have been limited despite comprehensive understanding of its genetic pathophysiology. Currently available therapies suffer from either poor clinical adherence to the regimen or potentially serious adverse effects. Recently, we employed atomic force miscopy (AFM) to identify L-cystine dimethylester (CDME) as an effective molecular imposter of L-cystine, capable of inhibiting crystal growth in vitro. More recently, we demonstrated CDME's efficacy in inhibiting L-cystine crystal growth in vivo utilizing a murine model of cystinuria. The application of AFM to discover inhibitors of crystal growth through structural mimicry suggests a novel approach to preventing and treating crystal diseases.

• Authors: Michael H Lee, Amrik Sahota, Michael D Ward, David S Goldfarb
• Journal: Current rheumatology reports (Curr Rheumatol Rep) Vol. 17 Issue 5 Pg. 33 (May 2015) ISSN: 1534-6307 [Electronic] United States
• PMID: 25874348 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• L-cystine dimethylester
• Cystine

Topics

• Animals
• Crystallization
• Cystine (analogs & derivatives, chemistry, therapeutic use)
• Cystinuria (complications, drug therapy)
• Drug Design
• Humans
• Kidney Calculi (etiology, prevention & control)
• Microscopy, Atomic Force (methods)
• Molecular Mimicry
• Molecular Targeted Therapy (methods)