Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells.

Abstract

Fangchinoline, an important compound in Stephania tetrandra S. Moore, as a novel antitumor agent, has been implicated in several types of cancers cells except gastric cancer. To investigate whether fangchinoline affects gastric cancer cells, we detected the signaling pathway by which fangchinoline plays a role in different human gastric cancer cells lines. We found that fangchinoline effectively suppressed proliferation and invasion of SGC7901 cell lines, but not MKN45 cell lines by inhibiting the expression of PI3K and its downstream pathway. All of the Akt/MMP2/MMP9 pathway, Akt/Bad pathway, and Akt/Gsk3β/CDK2 pathway could be inhibited by fangchinoline through inhibition of PI3K. Taken together, these results suggest that fangchinoline targets PI3K in tumor cells that express PI3K abundantly and inhibits the growth and invasive ability of the tumor cells.

• Authors: Feng Tian, Ding Ding, Dandan Li
• Journal: International journal of oncology (Int J Oncol) Vol. 46 Issue 6 Pg. 2355-63 ( 2015) ISSN: 1791-2423 [Electronic] Greece
• PMID: 25872479 (Publication Type: Journal Article, Retracted Publication)

Chemical References

• Antineoplastic Agents
• Benzylisoquinolines
• fangchinoline
• Phosphatidylinositol 3-Kinases
• Proto-Oncogene Proteins c-akt

Topics

• Antineoplastic Agents (pharmacology)
• Benzylisoquinolines (pharmacology)
• Cell Line, Tumor
• Cell Movement (drug effects)
• Cell Proliferation (drug effects)
• Gene Expression Regulation, Neoplastic
• HEK293 Cells
• Humans
• Phosphatidylinositol 3-Kinases (genetics, metabolism)
• Proto-Oncogene Proteins c-akt (genetics, metabolism)
• Signal Transduction (drug effects)
• Stomach Neoplasms (genetics, metabolism)